Publicado

2012-09-01

Solubility of acetaminophen in polyethylene glycol 400 + water mixtures according to the extended Hildebrand solubility approach

Palabras clave:

acetaminophen, binary mixtures, extended Hildebrand solubility approach, solubility parameter. (es)

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Autores/as

  • Edgar Ahumada Group of pharmaceutical-physicochemical research, Department of Pharmacy, Universidad Nacional de Colombia, PO Box 14490, Bogotá, D. C., Colombia.
  • Daniel Delgado Group of pharmaceutical-physicochemical research, Department of Pharmacy, Universidad Nacional de Colombia, PO Box 14490, Bogotá, D. C., Colombia.
  • Fleming Martínez Group of pharmaceutical-physicochemical research, Department of Pharmacy, Universidad Nacional de Colombia, PO Box 14490, Bogotá, D. C., Colombia.

The Extended Hildebrand Solubility Approach
(EHSA) was applied in the present
work to evaluate the solubility of the
analgesic drug acetaminophen (paracetamol)
in polyethylene glycol 400 + water
mixtures at 298.15 K. An acceptable
correlative capacity of EHSA was found
using a regular polynomial model in order
four (overall deviation below 0.7%),
when the W interaction parameter is related
to the solubility parameter of the
mixtures. Thus, the deviations obtained
in the estimated solubility with respect to
experimental solubility were lower than
those obtained directly by means of an
empiric regression of the experimental
solubility as a function of the mixtures’
solubility parameters (close to 1.5%).

Cómo citar

IEEE

[1]
E. Ahumada, D. Delgado, y F. Martínez, «Solubility of acetaminophen in polyethylene glycol 400 + water mixtures according to the extended Hildebrand solubility approach», Rev. Colomb. Quim., vol. 41, n.º 3, pp. 433–448, sep. 2012.

ACM

[1]
Ahumada, E., Delgado, D. y Martínez, F. 2012. Solubility of acetaminophen in polyethylene glycol 400 + water mixtures according to the extended Hildebrand solubility approach. Revista Colombiana de Química. 41, 3 (sep. 2012), 433–448.

ACS

(1)
Ahumada, E.; Delgado, D.; Martínez, F. Solubility of acetaminophen in polyethylene glycol 400 + water mixtures according to the extended Hildebrand solubility approach. Rev. Colomb. Quim. 2012, 41, 433-448.

APA

Ahumada, E., Delgado, D. y Martínez, F. (2012). Solubility of acetaminophen in polyethylene glycol 400 + water mixtures according to the extended Hildebrand solubility approach. Revista Colombiana de Química, 41(3), 433–448. https://revistas.unal.edu.co/index.php/rcolquim/article/view/42917

ABNT

AHUMADA, E.; DELGADO, D.; MARTÍNEZ, F. Solubility of acetaminophen in polyethylene glycol 400 + water mixtures according to the extended Hildebrand solubility approach. Revista Colombiana de Química, [S. l.], v. 41, n. 3, p. 433–448, 2012. Disponível em: https://revistas.unal.edu.co/index.php/rcolquim/article/view/42917. Acesso em: 29 mar. 2024.

Chicago

Ahumada, Edgar, Daniel Delgado, y Fleming Martínez. 2012. «Solubility of acetaminophen in polyethylene glycol 400 + water mixtures according to the extended Hildebrand solubility approach». Revista Colombiana De Química 41 (3):433-48. https://revistas.unal.edu.co/index.php/rcolquim/article/view/42917.

Harvard

Ahumada, E., Delgado, D. y Martínez, F. (2012) «Solubility of acetaminophen in polyethylene glycol 400 + water mixtures according to the extended Hildebrand solubility approach», Revista Colombiana de Química, 41(3), pp. 433–448. Disponible en: https://revistas.unal.edu.co/index.php/rcolquim/article/view/42917 (Accedido: 29 marzo 2024).

MLA

Ahumada, E., D. Delgado, y F. Martínez. «Solubility of acetaminophen in polyethylene glycol 400 + water mixtures according to the extended Hildebrand solubility approach». Revista Colombiana de Química, vol. 41, n.º 3, septiembre de 2012, pp. 433-48, https://revistas.unal.edu.co/index.php/rcolquim/article/view/42917.

Turabian

Ahumada, Edgar, Daniel Delgado, y Fleming Martínez. «Solubility of acetaminophen in polyethylene glycol 400 + water mixtures according to the extended Hildebrand solubility approach». Revista Colombiana de Química 41, no. 3 (septiembre 1, 2012): 433–448. Accedido marzo 29, 2024. https://revistas.unal.edu.co/index.php/rcolquim/article/view/42917.

Vancouver

1.
Ahumada E, Delgado D, Martínez F. Solubility of acetaminophen in polyethylene glycol 400 + water mixtures according to the extended Hildebrand solubility approach. Rev. Colomb. Quim. [Internet]. 1 de septiembre de 2012 [citado 29 de marzo de 2024];41(3):433-48. Disponible en: https://revistas.unal.edu.co/index.php/rcolquim/article/view/42917

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